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Abstract #0691

Functional MRI of mice olfactory bulbs at 15.2T reveals characteristic activation patterns when stimulated by different odors

Odélia Jacqueline Chitrit1, Qingjia Bao1, Silvia Chuartzman2, Noga Silkha2, Tali Kimchi2, and Lucio Frydman1
1Chemical and biological physics, Weizmann institute of Science, Rehovot, Israel, 2Neurobiology, Weizmann institute of Science, Rehovot, Israel


Single-shot fMRI executed at ultrahigh fields can reveal valuable insight about brain function, if it successfully overcomes field inhomogeneity problems. Spatiotemporal Encoding provides a route for achieving this, enabling studies on the olfactory bulbs of mice at 15.2T. Images collected with a 125 µm in-plane resolution yielded remarkably large and well-defined responses to olfactory cues, particularly in males. These were unambiguously linked to olfaction via single-nostril experiments. The experiments highlighted specific activation regions in the external plexiform region and in glomeruli in the lateral part of the bulb, when stimulated by aversive or appetitive odors, respectively.

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