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Abstract #0692

High-resolution MAP-MRI reveals cortical area specific laminar patterns observed with histological staining

Alexandru V Avram1,2, Kadharbatcha S Saleem1,2, Michal E Komlosh1,2, and Peter J Basser1
1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, The Henry Jackson Foundation, Bethesda, MD, United States


We investigate the sensitivity of high-resolution MAP-MRI to distinguish cortical architectonic features by directly comparing laminar patterns in whole-brain volumes of MAP-derived parameters to the corresponding histological sections in the same macaque monkey brain. MAP parameters, in particular PA, NG, RTAP, DEC, and fODF maps, show cortical area-specific lamination patterns with excellent conspicuity in the mid-cortical layers, matching, and sometimes complementing, the contrast observed in the immuno- or histochemically stained sections. Delineating cortical areas with distinct cytoarchitectonic features non-invasively based on diffusion propagators could transform our ability to study brain networks and diagnose subtle microstructural changes in many clinical applications.

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