The neonatal brain relies primarily on oxygen metabolism to meet its enormous energy demands. Cerebral venous oxygenation (Yv) is an important parameter of the brain’s oxygen utilization, and has been demonstrated to be a potential biomarker in various neonatal diseases. We previously developed two non-invasive MRI techniques, TRUPC and accelerated-TRUPC, to measure Yv in the neonatal brain. In this work, we validated the accuracy of these two techniques by comparing their Yv measurements with gold-standard blood gas oximetry on a piglet model, and demonstrated that TRUPC and accelerated-TRUPC can provide accurate quantifications of Yv.
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