Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: a graded-O2 study in piglets
Dengrong Jiang1, Raymond C. Koehler2, Xiuyun Liu2, Ewa Kulikowicz2, Jennifer K. Lee2, Hanzhang Lu1,3,4, and Peiying Liu1
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States
The neonatal brain relies primarily on oxygen metabolism to meet its enormous energy demands. Cerebral venous oxygenation (Yv) is an important parameter of the brain’s oxygen utilization, and has been demonstrated to be a potential biomarker in various neonatal diseases. We previously developed two non-invasive MRI techniques, TRUPC and accelerated-TRUPC, to measure Yv in the neonatal brain. In this work, we validated the accuracy of these two techniques by comparing their Yv measurements with gold-standard blood gas oximetry on a piglet model, and demonstrated that TRUPC and accelerated-TRUPC can provide accurate quantifications of Yv.
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