Novel non-invasive determination of parasagittal dural volume and cerebrospinal fluid flux: assessment of glymphatic clearance mechanisms
Kilian Hett1, Colin D. McKnight2, Jarrod J. Eisma1, Jason Elenberger1, Ciaran M. Considine1, Daniel O. Claassen1, and Manus J. Donahue1,3
1Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States
Despite prior assumptions that the brain is devoid of lymphatic vessels, emerging evidence indicates that lymphatic vessels are present in the region alongside the superior sagittal sinus, the parasagittal dural (PSD) space, and could play a critical role in waste clearance or glymphatic physiology. However, limited methods are available for interrogating this space non-invasively in vivo. Here, in 62 healthy participants we apply novel deep learning algorithms in sequence with anatomical and phase contrast cerebrospinal fluid (CSF) flow assessments to test fundamental hypotheses regarding how PSD volume evolves across the lifespan and relates to measures of CSF flux and volume.
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