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Abstract #0719

Examining cerebrovascular burden across the cognitive continuum in older adults with and without evidence of amyloidosis

Leonardo A Rivera-Rivera1, Karly A Cody1, Tobey A Betthauser1, Rebecca Koscik1, Erin Jonaitis 1, Robert Cadman1, Bruce Hermann1, Howard A Rowley1, Cynthia M Carlsson1, Nathaniel Chin1, Laura Eisenmenger1, Sterling C Johnson1, and Kevin M Johnson1
1University of Wisconsin, Madison, Madison, WI, United States


In this study we investigated cerebrovascular health and vascular contributions to cognitive impairment in the presence and absence of amyloidosis. We employed various neuroimaging techniques including 4D-Flow, multi-delay ASL, T2-FLAIR, and structural T1 for vascular and structural biomarkers. β-amyloid (Aβ) burden was determined from PET imaging data. Data supports the notion that vascular dysfunction occurs in the presence and absence of , albeit with differing manifestations leading to cognitive decline.

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