In this study we investigated cerebrovascular health and vascular contributions to cognitive impairment in the presence and absence of amyloidosis. We employed various neuroimaging techniques including 4D-Flow, multi-delay ASL, T2-FLAIR, and structural T1 for vascular and structural biomarkers. β-amyloid (Aβ) burden was determined from PET imaging data. Data supports the notion that vascular dysfunction occurs in the presence and absence of Aβ, albeit with differing manifestations leading to cognitive decline.
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