Abstract #0720
Blood-brain barrier water exchange rate is associated with cognitive performance in mild cognitive impairment and early Alzheimer’s disease
Catherine A Morgan1,2,3, Xingfeng Shao4, Jane Govender2, Tabitha Manson5, Vinod Suresh5,6, Deidre Jansson7, Danny JJ Wang4, David L Thomas8,9, Lynette Tippett1,2, and Michael Dragunow7
1School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand, 2Brain Research New Zealand - Rangahau Roro Aotearoa, Centre of Research Excellence, New Zealand, Auckland, New Zealand, 3Centre for Advanced MRI, University of Auckland, Auckland, New Zealand, 4Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, 6Department of Engineering Science, University of Auckland, Auckland, New Zealand, 7Department of Pharmacology and Centre for Brain Research, University of Auckland, Auckland, New Zealand, 8Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 9Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
Synopsis
Blood-brain barrier (BBB) dysfunction has been observed in multiple neurodegenerative conditions, including mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However recent concerns on the repeated use of Gadolinium based contrast agents (GBCAs), prompted us to investigate alternative, non-invasive methods for measuring BBB health. Diffusion-prepared arterial spin labelling (DP-ASL) imaging was implemented at 3T to determine water exchange rates (Kw) in 55 participants, comprising MCI, early AD and control participants. We found Kw to be associated with cognitive performance, suggesting it may be a useful imaging biomarker of early AD pathology.
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