Visualizing oxygen transport in real time in the murine placenta at 15.2T
Talia Harris1, Michal Neeman2, and Lucio Frydman3
1Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel, 23Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 3Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel
We demonstrate that with the high signal to noise and sensitivity to oxygenation at 15.2 T we can visualize the transport of oxygen across the murine placenta with temporal resolution of 20s. Changes in the R2* of the placenta and embryo heart, observed upon switching from 100% O2 to 10% and switching back to 100% O2, exhibit different dynamic behavior than the maternal blood vessels, specifically a delayed response compared to the maternal blood vessels and a much slower response when switching from 10% O2 to 100% O2.
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