Abstract #0726

Maternal Blood Volume Measurements of Human Placenta with Fetal Growth Restriction using Ferumoxytol-Enhanced MRI

Ruiming Chen¹, Sean B. Fain^1,2, Ronald R. Magness³, Kathleen M. Antony^4,5,6, J. Igor Iruretagoyena⁴, Ian M. Bird⁴, Dinesh M. Shah⁴, Oliver Wieben^1,2,7, and Kevin M. Johnson^1,7

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ³Obstetrics & Gynecology, University of South Florida, Tampa, FL, United States, ⁴Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ⁶Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, ⁷Radiology, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Fetal growth restriction (FGR) has been associated with insufficient development of utero-placental vasculature, which could be identified using maternal placental blood volume measurements. This preliminary study uses ferumoxytol-enhanced MRI to measure placental blood volume of three FGR subjects using variable flip angle T1-mapping. Mean values of maternal fractional, placental, and total blood volumes are reported, as well as changes in placental R1 values between two time points after contrast injection. We observe local placental heterogeneities, including regions with low factional blood volume in the subjects.

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