Abstract #0727
Quantifying Placental Structure and Function over Gestation with Combined T2*-diffusion MRI
Paddy J. Slator1, Jana Hutter2,3, Laurence H. Jackson2,3, Alison Ho4, Lisa Story4, Lucy C. Chappell4, Mary Rutherford2, Joseph V. Hajnal2,3, and Daniel C. Alexander1
1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 4Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom
Synopsis
We quantify placental structure and function over gestation with combined diffusion-relaxometry MRI. We apply a simultaneous T2*-diffusion acquisition protocol to a cohort of 65 pregnant participants, and hence estimate T2* and ADC maps, T2*-ADC spectra, and map T2*-ADC spectrum components with a data-driven technique, InSpect. We show InSpect is more sensitive to placental maturation than separate T2* and ADC mapping alone.
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