Abstract #0727

Quantifying Placental Structure and Function over Gestation with Combined T2*-diffusion MRI

Paddy J. Slator¹, Jana Hutter^2,3, Laurence H. Jackson^2,3, Alison Ho⁴, Lisa Story⁴, Lucy C. Chappell⁴, Mary Rutherford², Joseph V. Hajnal^2,3, and Daniel C. Alexander¹

¹Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ²Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁴Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom

Synopsis

We quantify placental structure and function over gestation with combined diffusion-relaxometry MRI. We apply a simultaneous T2*-diffusion acquisition protocol to a cohort of 65 pregnant participants, and hence estimate T2* and ADC maps, T2*-ADC spectra, and map T2*-ADC spectrum components with a data-driven technique, InSpect. We show InSpect is more sensitive to placental maturation than separate T2* and ADC mapping alone.

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