Abstract #0741

Regional assessment of cerebral oxygen extraction fraction in neonates with hypoxic-ischemic-encephalopathy: a pilot study

Dengrong Jiang¹, W. Christopher Golden², Aylin Tekes¹, Charlamaine Parkinson², Bruno Soares¹, Avner Meoded¹, Hanzhang Lu^1,3,4, Frances Northington², and Peiying Liu^1,5

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ⁵Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Hypoxic-ischemic-encephalopathy (HIE) is the leading cause of neonatal mortality and severe neurological impairment in childhood. Quantification of cerebral oxygen-extraction-fraction (OEF) in neonates with HIE may provide valuable information to guide the treatment and predict clinical outcome. In this pilot study, we used a novel MRI technique, accelerated-T₂-relaxation-under-phase-contrast (aTRUPC), to measure regional OEF in neonates with HIE. We demonstrated a trend towards lower cortical OEF in HIE neonates compared to healthy controls. In addition, neonates with severer brain injury had lower cortical OEF. These findings suggest that regional OEF measurement may be useful in evaluating cerebral injuries in HIE.

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