Regional assessment of cerebral oxygen extraction fraction in neonates with hypoxic-ischemic-encephalopathy: a pilot study
Dengrong Jiang1, W. Christopher Golden2, Aylin Tekes1, Charlamaine Parkinson2, Bruno Soares1, Avner Meoded1, Hanzhang Lu1,3,4, Frances Northington2, and Peiying Liu1,5
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 5Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
Hypoxic-ischemic-encephalopathy (HIE) is the leading cause of neonatal mortality and severe neurological impairment in childhood. Quantification of cerebral oxygen-extraction-fraction (OEF) in neonates with HIE may provide valuable information to guide the treatment and predict clinical outcome. In this pilot study, we used a novel MRI technique, accelerated-T2-relaxation-under-phase-contrast (aTRUPC), to measure regional OEF in neonates with HIE. We demonstrated a trend towards lower cortical OEF in HIE neonates compared to healthy controls. In addition, neonates with severer brain injury had lower cortical OEF. These findings suggest that regional OEF measurement may be useful in evaluating cerebral injuries in HIE.
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