The effects of preterm birth on GABA+, Glx and GSH in the neonatal brain
Maria Yanez Lopez1, Anthony N Price1, Nicolaas AJ Puts2, Emer J Hughes1, Richard AE Edden3, Grainne M McAlonan2, Tomoki Arichi1, and Enrico De Vita4
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 2Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK, London, United Kingdom
We have performed the first simultaneous measurement of GABA+, Glx and GSH in the preterm brain. Our main findings show that GABA+ and Glx significantly increased with postmenstrual age in preterm neonates during the 31-45 week period. We additionally found that metabolites underpinning glutamate and GABA neurotransmission levels in preterm babies were significantly lower than normative neonatal values, even when measured at the term time equivalent timepoint. We also identified higher GABA+ and Glx in the thalamus compared with the cortex. Our findings provide further support for the application of edited MRS in neurodevelopment.
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