Infancy is one of the most prominent times of daily energy expenditure across the lifespan. Here, using cutting-edge pCASL with high-resolution at isotropic 2.5mm and phase-contrast MRI, we delineated the developmental trajectory of the infant’s global and regional cerebral blood flow (rCBF) supporting the metabolic needs for brain development in 0-28months. Significant age-related CBF increases during infancy were better modeled with biphasic linear models, with break-point ages observed earlier in sensorimotor and auditory cortices and later in association cortices. The established population-averaged rCBF maps across infancy can serve as normative rCBF atlases for neuroscientific research or clinical care.
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