A biphasic pattern of cerebral blood flow increases during infancy revealed with 3D multi-shot, stack-of-spirals pCASL and phase-contrast MRI
Minhui Ouyang1,2, John Detre3, Jessica L Hyland1, Kay Laura Sindabizera1, Yun Peng4, J. Christopher Edgar1,2, and Hao Huang1,2
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, China
Infancy is one of the most prominent times of daily energy expenditure across the lifespan. Here, using cutting-edge pCASL with high-resolution at isotropic 2.5mm and phase-contrast MRI, we delineated the developmental trajectory of the infant’s global and regional cerebral blood flow (rCBF) supporting the metabolic needs for brain development in 0-28months. Significant age-related CBF increases during infancy were better modeled with biphasic linear models, with break-point ages observed earlier in sensorimotor and auditory cortices and later in association cortices. The established population-averaged rCBF maps across infancy can serve as normative rCBF atlases for neuroscientific research or clinical care.
This abstract and the presentation materials are available to members only;
a login is required.