EPTI is a highly accelerated time-resolved imaging method for rapid quantitative imaging. To improve the spatiotemporal encoding efficiency of EPTI, we developed a “circular” EPTI sampling trajectory (cEPTI), designed to efficiently traverse a tight circular k-space coverage with full ramp-sampling. A systematic approach was also developed to characterize the noise and effective resolution of the EPTI acquisition and used to guide the optimization of cEPTI’s k-t sampling trajectory. The optimized cEPTI was demonstrated to be capable of producing a 50ms time-resolved series of distortion-free sharp brain images with varying T2* weightings at 1 mm in-plane resolution from a 195ms scan.
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