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Abstract #0763

Towards a gold standard for fiber orientations in the brain: Validating dMRI using scattered light and X-ray imaging

Marios Georgiadis1, Miriam Menzel2, David Gräßel2, Ivan Rajkovic3, Donald Born1, Markus Axer2, and Michael Zeineh1
1Stanford University School of Medicine, Stanford, CA, United States, 2Institute of Neuroscience and Medicine (INM-1), Forschungszentrum J├╝lich, Julich, Germany, 3Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, United States

Synopsis

Generating a detailed network model of the brain requires a correct mapping of fiber orientations. Diffusion MRI is sensitive to neuronal alignment, yet each voxel contains hundreds of axons and other structures. Light and X-ray scattering can reveal more detailed information about nerve fibers, with much higher resolution and specificity respectively. Here we combine two methods, namely Scattered Light Imaging (SLI) and 3D-scanning small-angle X-ray scattering (3D-sSAXS), aiming to provide a micrometer-resolution gold standard for fiber orientation imaging. We compare that to high-resolution diffusion MRI of a region with challenging fiber orientations, the corona radiata, in human and non-human primates.

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