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Abstract #0765

Axonal diffusivities from two-shell PGSE data

Marco Pizzolato1,2,3, Mariam Andersson3, Erick Jorge Canales-Rodríguez2, and Tim Bjørn Dyrby1,3
1Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark


The strongly diffusion-weighted MRI signal contains information about the axonal parallel and perpendicular diffusivities. Powder averaging has simplified the estimation of the perpendicular diffusivity, however it is difficult to estimate the parallel one because, as we show, the powder-averaged signal at strong diffusion weightings is insensitive to it. In this work we propose a method that enables the estimation of both diffusivities from only two conventional linear PGSE signal shells collected at high b-values. The method is tested on public MGH-HCP data to retrieve axonal diffusivities and calculate the MR radius in white matter.

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