The strongly diffusion-weighted MRI signal contains information about the axonal parallel and perpendicular diffusivities. Powder averaging has simplified the estimation of the perpendicular diffusivity, however it is difficult to estimate the parallel one because, as we show, the powder-averaged signal at strong diffusion weightings is insensitive to it. In this work we propose a method that enables the estimation of both diffusivities from only two conventional linear PGSE signal shells collected at high b-values. The method is tested on public MGH-HCP data to retrieve axonal diffusivities and calculate the MR radius in white matter.
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