Abstract #0766

Longitudinal evaluation of bundle-wise diffusion metrics in a region of fiber crossing for axonal degeneration and inflammation

Ricardo Coronado-Leija¹, Omar Narvaez², Ricardo Rios³, Benoit Scherrer⁴, Alonso Ramirez-Manzanares⁵, and Luis Concha³

¹Radiology, New York University School of Medicine, New York, NY, United States, ²University of Eastern Finland, Kuopio, Finland, ³Institute of Neurobiology, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico, ⁴Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ⁵Center of Research in Mathematics, Guanajuato, Mexico

Synopsis

Single fiber methods, such as the diffusion tensor, cannot accurately determine per-bundle characteristics in voxels occupied by multiple axonal populations specially in the case of pathology when they have different diffusion properties. In this work, we used animal models of axonal degeneration and inflammation to evaluate longitudinally the sensitivity of bundle specific metrics provided by three multi-fiber methods in a region of crossing fiber in which only one fiber population is injured.

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