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Abstract #0766

Longitudinal evaluation of bundle-wise diffusion metrics in a region of fiber crossing for axonal degeneration and inflammation

Ricardo Coronado-Leija1, Omar Narvaez2, Ricardo Rios3, Benoit Scherrer4, Alonso Ramirez-Manzanares5, and Luis Concha3
1Radiology, New York University School of Medicine, New York, NY, United States, 2University of Eastern Finland, Kuopio, Finland, 3Institute of Neurobiology, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico, 4Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 5Center of Research in Mathematics, Guanajuato, Mexico


Single fiber methods, such as the diffusion tensor, cannot accurately determine per-bundle characteristics in voxels occupied by multiple axonal populations specially in the case of pathology when they have different diffusion properties. In this work, we used animal models of axonal degeneration and inflammation to evaluate longitudinally the sensitivity of bundle specific metrics provided by three multi-fiber methods in a region of crossing fiber in which only one fiber population is injured.

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