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Abstract #0767

Comparison of diffusion MRI models for white matter in simulations and in early human brain development

Ying Liao1, Santiago Coelho1, Jenny Chen1, Benjamin Ades-Aron1, Dmitry S. Novikov1, and Els Fieremans1
1Radiology, NYU School of Medicine, New York, NY, United States


Biophysical modeling of diffusion MRI is instrumental in achieving specificity to tissue microstructure in human white matter. The “Standard Model” (SM) framework encompasses many approaches assuming multiple Gaussian compartments. To robustly estimate SM parameters, different constraints and techniques have been applied, resulting in different outcomes. Here we evaluate the precision and accuracy of commonly used implementations and constraints for SM parameter estimation, and compare their results both in simulations and in early human brain development.

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