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Abstract #0775

In vivo myelin thickness estimates from DIffusion-Prepared Phase Imaging (DIPPI)

Michiel Cottaar1, Wenchuan Wu1, Karla Miller1, and Saad Jbabdi1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom


DIPPI is a novel sequence that allows the measurement of the off-resonance field experienced by intra-axonal water, which in myelinated axons is modulated by the surrounding myealin sheath allowing for estimation of the g-ratio. Unlike other g-ratio imaging methods, DIPPI does not rely on combining multiple modalities and can provide g-ratio estimates for individual crossing fibre populations rather than averaged over voxels. We present the first in-vivo DIPPI measurements and correct it for confounds such as subject movement and eddy currents. We then estimate the g-ratio in multiple white matter tracts from the processed off-resonance field maps.

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