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Abstract #0774

Resolve fiber crossings using orientation distribution function (ODF) of decomposed sub-voxel paramagnetic and diamagnetic susceptibility

Jingjia Chen1, Dimitrios Gkotsoulias2, Jennifer Jaffe3,4, Catherine Crockford3,4, Roman Wittig3,4, Harald E. Möller2, and Chunlei Liu1,5
1Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, 2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, 4Taï Chimpanzee Project, Centre Suisse de Recherches Scientifiques en Côte d’Ivoire, Abidjan, Cote D'ivoire, 5Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States


DECOMPOSE-QSM was applied on high angular-resolution multi-echo gradient-echo data of a chimpanzee brain to evaluate its ability in resolving orientation mixture of substructure fiber bundles. The orientation distribution function (ODF) of the separated paramagnetic and diamagnetic susceptibility provides smooth transitions of multiple fiber orientations. Additionally, the paramagnetic maps from DECOMPOSE show a potential to resolve fiber crossings in deep gray matter regions.

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