Abstract #0783

Identification of ’black hole’ T1 hypointense lesions using different intensity thresholds on gradient-echo T1w MRI

Vanessa Wiggermann¹, Mie Arnau Martinez¹, Jasmin Merhout¹, Jeppe Romme Christensen², Morten Blinkenberg², Finn Sellebjerg^2,3, Henrik Lundell^1,4, and Hartwig Roman Siebner^1,5

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark, ²Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Glostrup, Denmark, ³Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ⁴Health Technology, Technical University of Denmark, Lyngby, Denmark, ⁵Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

Synopsis

Black holes (BHs), T1 hypointense lesions, are known predictors of multiple sclerosis disease severity, however, their identification is strongly intensity dependent. As traditional spin-echo T1 scans are being replaced by 3D gradient-echo images, we need to understand how hypointense lesions on these images compare. We assessed whether an intensity threshold for MPRAGE images exists that would allow to match spin-echo black hole definitions. Simple thresholding was only able to reproduce black hole segmentations to an intermediate degree.

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