Identification of ’black hole’ T1 hypointense lesions using different intensity thresholds on gradient-echo T1w MRI
Vanessa Wiggermann1, Mie Arnau Martinez1, Jasmin Merhout1, Jeppe Romme Christensen2, Morten Blinkenberg2, Finn Sellebjerg2,3, Henrik Lundell1,4, and Hartwig Roman Siebner1,5
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark, 2Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Glostrup, Denmark, 3Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 4Health Technology, Technical University of Denmark, Lyngby, Denmark, 5Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark
Black holes (BHs), T1 hypointense lesions, are known predictors of multiple sclerosis disease severity, however, their identification is strongly intensity dependent. As traditional spin-echo T1 scans are being replaced by 3D gradient-echo images, we need to understand how hypointense lesions on these images compare. We assessed whether an intensity threshold for MPRAGE images exists that would allow to match spin-echo black hole definitions. Simple thresholding was only able to reproduce black hole segmentations to an intermediate degree.
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