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Abstract #0786

Clinical correlates of brain iron and myelin changes in Multiple Sclerosis: a multi-parameter quantitative MRI study

Giuseppe Pontillo1, Maria Petracca1, Serena Monti2, Mario Quarantelli2, Roberta Lanzillo1, Teresa Costabile3, Antonio Carotenuto1, Fabio Tortora1, Andrea Elefante1, Vincenzo Brescia Morra1, Arturo Brunetti1, Giuseppe Palma2, and Sirio Cocozza1
1University of Naples "Federico II", Naples, Italy, 2Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy, 3Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy


In this cross-sectional study, voxel-based morphometry and voxel-based quantification analyses of longitudinal relaxation rate (R1) and quantitative susceptibility (QSM) maps, reflecting myelin and iron, respectively, were conducted on 117 patients with MS (pwMS) and 53 healthy controls. Between-group differences and correlations with clinical variables (global disability, cognitive and motor performance) were assessed. We found widespread atrophy and R1 decrease in pwMS, with smaller clusters of reduced susceptibility in the thalami and cerebral WM. While subcortical atrophy and WM iron depletion contributed to global and motor disability, deep GM atrophy and R1 decrease in lesional areas correlated with cognitive performance.

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