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Abstract #0785

Multiple sclerosis related fatigue: Altered resting-state functional connectivity of the Default Mode Network.

Yujing Li1, Jun Wang1, Tingli Yang1, Pengfei Zhang1, Kai Ai2, Xiaoli He1, Haiying Zhao1, Yuan Ding1, Rui Wang1, Min Li1, Xinying Ren1, Diaohan Xiong1, and Jing Zhang1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi’an, China


The objective of this study was to elucidate the no-motor component of fatigue mechanism in multiple sclerosis (MS) patients by studying the resting state functional connectivity (RS-FC) of default mode network (DMN). 12 with fatigue (F) and 10 without fatigue (nF) MS underwent resting sate magnetic resonance imaging (MRI). We selected 11 priori regions within the DMN as the regions of interests (ROIs) and ROI to ROI and ROI to global FC were calculated. Compared to nF-MS patients, F-MS patients showed abnormal increased functional connectivity in brain regions associated with cognitive function within the DMN.

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