Investigating Cerebral Perfusion with High Resolution Hyperpolarized [1-13C]Pyruvate MRI
Jasmine Y Hu1,2, Sana Vaziri1, Nikolaj Bogh3, Yaewon Kim1, Adam W Autry1, Robert A Bok1, Yan Li1,2, Christoffer Laustsen3, Peder EZ Larson1,2, Duan Xu1,2, Daniel B Vigneron1,2, and Jeremy W Gordon1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Bioengineering, University of California Berkeley, Berkeley, CA, United States, 3MR Research Center, Clinical Medicine, Aarhus University, Aarhus, Denmark
Acquiring high resolution 7.5 mm2 hyperpolarized [1-13C]pyruvate brain MRI allows for finer spatial delineation of brain structures and can be used to obtain cerebral perfusion parameters. In the healthy volunteers studied, pyruvate rCBV and rCBF were positively correlated to ASL perfusion values. Hyperpolarized pyruvate MRI can be used to assess cerebral metabolism and perfusion within the same study.
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