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Abstract #0806

Feasibility of Flow-related Enhancement Brain Perfusion MRI

Julian Glandorf1, Filip Klimes1, Andreas Voskrebenzev1, Marcel Gutberlet1, Agilo Luitger Kern1, Norman Kornemann1, Nima Mahmoudi2, Mike Peter Wattjes2, Frank Wacker1, and Jens Vogel-Claussen1
1Institut für Diagnostische und Interventionelle Radiologie, Hannover Medical School, Hannover, Germany, 2Institut für Diagnostische und Interventionelle Neuroradiologie, Hannover Medical School, Hannover, Germany


To test the feasibility of brain perfusion imaging exploiting flow-related enhancement during fast gradient echo sequences. Imaging was performed using Fast Low-Angle Shot (FLASH) and balanced steady-state free precession (bSSFP) sequences of a single axial slice with various imaging parameters at 1.5T and 3T. Perfusion-weighted maps were generated based on the Fourier decomposition method “Phase-REsolved FUnctional Lung” (PREFUL) MRI. The derived imaging protocol was evaluated in patients with metastases and a stroke showing high spatial overlap to post-contrast MRI and CT-perfusion. A cohort of 19 healthy individuals presented moderate, but significant regional correlation and high spatial Dice overlap to pCASL-MRI.

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