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Abstract #0814

Multi-modal MRI reveals changes in placental function following preterm premature rupture of membranes

Andrew Melbourne1, Carla Avena Zampieri1, Dimitra Flouri1, Joseph V Hajnal1, Anna David2, Mary A Rutherford1, Jana Hutter3, and Lisa Story4
1Centre for Medical Engineering, King's College London, London, United Kingdom, 2University College London, London, United Kingdom, 3King's College London, London, United Kingdom, 4Women's Health, King's College London, London, United Kingdom


Preterm premature rupture of membranes (PPROM) complicates up to 40% of deliveries less than 37 completed weeks gestation. Absence of clinical symptoms means that fetal infection can be missed and later complications are significantly higher. There is thus a real need for non-invasive antenatal assessment of the early signs of placental inflammation. This study combines an efficient multimodal Diffusion-Relaxation acquisition with dedicated analysis to study the placental phenotype associated with PPROM. Initial results indicate that multi-modal MRI measurement of placental function is linked to eventual gestational age at delivery.

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