Abstract #0815

Structural-functional interplay of the human placenta: in-vivo study using Pseudocontinuous Arterial Spin Labeling

Daphna Link¹, Netanell Avisdris^1,2, Xingfeng Shao³, Liat Ben Sira^4,5, Liran Hiersch⁶, Ilan Gull⁷, Danny J.J. Wang⁸, and Dafna Ben Bashat^1,4

¹Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, ³Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁴Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ⁵Division of Pediatric Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁶Division of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Ultrasound Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁸3Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

Adequate placental structure and function are crucial for fetal and maternal health. Here we assessed late-gestation placental perfusion (N=50, GA=31-38 weeks) using pseudocontinuous arterial-spin-labeling and radiomics feature-extraction, and their association with umbilical-cord insertion-site and the risk of fetal-growth-restriction (FGR). Increased blood-flow and arterial-transit-time were detected in our normal cases compared to earlier gestation as reported previously. Perfusion features differences were detected in placentas with marginal compared to central cord-insertion, indicating higher intensity heterogeneity. No differences were found between normal and FGR placentas. This study provides normal late-gestation placental perfusion values based on a large cohort, and implies on structural-functional associations.

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