Effects of Life-Long Maternal Western Diet on Guinea Pig Placental Metabolism Across Gestation using [1-13C]pyruvate MRI
Lindsay E. Morris1, Lanette J. Friesen-Waldner1, Trevor P. Wade1, Lauren M. Smith2, Mary-Ellen ET. Empey1, Timothy RH. Regnault3,4,5, and Charles A. McKenzie1,5
1Medical Biophysics, Western University, London, ON, Canada, 2Radiation Oncology, University of California Los Angeles Health, Los Angeles, CA, United States, 3Physiology and Pharmacology, Western University, London, ON, Canada, 4Obstetrics and Gynaecology, Western University, London, ON, Canada, 5Division of Maternal, Fetal and Newborn Health, Children's Health Research Institute, London, ON, Canada
Effects of a life-long maternal Western Diet (WD: high fat and high sugar diet) on placental metabolism in 33- and 60-day gestation guinea pigs were investigated. Pregnant WD or control diet (CD) fed sows underwent T1-weighted and 13C hyperpolarized metabolic MRI at 3T. Metabolite mean signal intensities were measured in the placental volumes as a function of time and area under the curve (AUC) ratios were calculated for pyruvate and its metabolites: lactate, bicarbonate & alanine. The AUC ratios for lactate and bicarbonate were significantly higher in WD than CD groups, suggesting placental metabolic dysfunction.
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