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Abstract #0817

Ferumoxytol-Enhanced T2* Mapping of Human Placenta with Fetal Growth Restriction

Ruiming Chen1, Ante Zhu2, Kevin M. Johnson1,3, Ian M. Bird4, Kathleen M. Antony4, J. Igor Iruretagoyena4, Scott B. Reeder1,3,4,5,6, Diego Hernando1,3,7,8, Dinesh M. Shah4, and Oliver Wieben1,3
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2GE Global Research, Niskayuna, NY, United States, 3Radiology, University of Wisconsin - Madison, Madison, WI, United States, 4Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 5Medicine, University of Wisconsin - Madison, Madison, WI, United States, 6Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States, 7Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 8Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Fetal growth restriction (FGR) is associated with placental hypoxia, which can be identified by measuring placental T2* value in-vivo. In this pilot study, we acquired T2* maps in 2 subjects in late pregnancy diagnosed with FGR. Mean and histogram of T2* and R2* values in the placenta were analyzed for two timepoints after administration of ferumoxytol reflecting T2* maps dominated by the presence of the iron nanoparticles and a baseline. We observed lower baseline T2* values than previously reported in healthy controls at similar gestation as well as lower baseline T2* values as reported in FGR patients earlier in gestation.

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