Abstract #0817

Ferumoxytol-Enhanced T2* Mapping of Human Placenta with Fetal Growth Restriction

Ruiming Chen¹, Ante Zhu², Kevin M. Johnson^1,3, Ian M. Bird⁴, Kathleen M. Antony⁴, J. Igor Iruretagoyena⁴, Scott B. Reeder^1,3,4,5,6, Diego Hernando^1,3,7,8, Dinesh M. Shah⁴, and Oliver Wieben^1,3

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²GE Global Research, Niskayuna, NY, United States, ³Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁷Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁸Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Fetal growth restriction (FGR) is associated with placental hypoxia, which can be identified by measuring placental T2* value in-vivo. In this pilot study, we acquired T2* maps in 2 subjects in late pregnancy diagnosed with FGR. Mean and histogram of T2* and R2* values in the placenta were analyzed for two timepoints after administration of ferumoxytol reflecting T2* maps dominated by the presence of the iron nanoparticles and a baseline. We observed lower baseline T2* values than previously reported in healthy controls at similar gestation as well as lower baseline T2* values as reported in FGR patients earlier in gestation.

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