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Abstract #0867

Comparison of image and extracorporeal derived arterial input functions for DCE-MRI in mice using an multimodal cross-validation approach

Florian Gierse1, Juela Cufe1, Bastian Maus2, Katharina Kronenberg3, Michael Claesener4, Paulina Dorten1, Klaus Schäfers1, Sven Hermann1, Uwe Karst3, Cornelius Faber2, Michael Schäfers4, Florian Büther4, and Philipp Backhaus4
1European Institute for Molecular Imaging, University of Münster, Münster, Germany, 2Translational Research Imaging Center, University of Münster, Münster, Germany, 3Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany, 4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany


Quantitative precise measurements of the dynamic arterial blood concentration (AIF) are challenging in perfusion MRI. As solution an extracorporeal circulation approach for the AIF determination with two different vascular access ways is presented and cross validated with injection of radioactive contrast agent derivatives. Independent of the vascular access way, extracorporeal derived AIFs point towards a high quantitative precision, although dispersion must be considered. However, deconvolution methods based on single gamma variate functions end up in plausible AIFs. The use of novel rapid imaging techniques in connection with extracorporeal AIFs indicates high potential for precise quantitative dual PET/MRI Pharmacokinetic-Modeling in mice.

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