Abstract #0867

Comparison of image and extracorporeal derived arterial input functions for DCE-MRI in mice using an multimodal cross-validation approach

Florian Gierse¹, Juela Cufe¹, Bastian Maus², Katharina Kronenberg³, Michael Claesener⁴, Paulina Dorten¹, Klaus Schäfers¹, Sven Hermann¹, Uwe Karst³, Cornelius Faber², Michael Schäfers⁴, Florian Büther⁴, and Philipp Backhaus⁴

¹European Institute for Molecular Imaging, University of Münster, Münster, Germany, ²Translational Research Imaging Center, University of Münster, Münster, Germany, ³Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany, ⁴Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

Synopsis

Quantitative precise measurements of the dynamic arterial blood concentration (AIF) are challenging in perfusion MRI. As solution an extracorporeal circulation approach for the AIF determination with two different vascular access ways is presented and cross validated with injection of radioactive contrast agent derivatives. Independent of the vascular access way, extracorporeal derived AIFs point towards a high quantitative precision, although dispersion must be considered. However, deconvolution methods based on single gamma variate functions end up in plausible AIFs. The use of novel rapid imaging techniques in connection with extracorporeal AIFs indicates high potential for precise quantitative dual PET/MRI Pharmacokinetic-Modeling in mice.

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