Mapping Rodent Brain Mechanical Properties In Vivo with Magnetic Resonance Elastography and Nonlinear Inversion
L. Tyler Williams1, Katrina A. Milbocker2, Seth R. Sullivan1, Ian F. Smith2, Eric Brengel2, Gillian LeBlanc2, Anna Y. Klintsova2, Matthew D. J. McGarry3, and Curtis L. Johnson1
1Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Psychological & Brain Sciences, University of Delaware, Newark, DE, United States, 3Thayer School of Engineering, Dartmouth College, Hanover, NH, United States
Developing preclinical MRE techniques that are comparable to human MRE is important for translational studies. This pilot study investigates the efficacy of the nonlinear inversion algorithm on rat brain MRE data. Whole-brain MRE scans were performed on female, Long-Evans rats using a custom MRE-EPI sequence and piezoelectric actuator with a resolution of 0.25 mm isotropic and with 600 Hz vibration. NLI parameters were adjusted for brain size and frequency. The resulting shear stiffness and damping ratio maps exhibited strong contrast between different anatomical regions. These results validate the use of NLI in preclinical MRE settings.
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