Abstract #0889

Magnetic Resonance Fingerprinting enables measuring T1-shortening in multiple sclerosis lesions after contrast media administration

Graziella Donatelli^1,2, Paolo Cecchi^1,2, Gianmichele Migaleddu¹, Matteo Cencini³, Claudio D'Amelio⁴, Guido Buonincontri³, Luca Peretti^2,3,4, Livia Pasquali⁴, Michela Tosetti^2,3, Mirco Cosottini⁴, and Mauro Costagli^3,5

¹Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, ²IMAGO 7 Research Foundation, Pisa, Italy, ³IRCCS Stella Maris, Pisa, Italy, ⁴University of Pisa, Pisa, Italy, ⁵Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Sciences, University of Genoa, Genoa, Italy

Synopsis

Quantitative maps of T1-shortening (ΔT1) related to intra-venous contrast media administration are obtained in patients with Multiple Sclerosis by using 3D Quantitative Transient-state Imaging. Statistically significant ΔT1 is observed not only in enhancing lesions, but also in some non-enhancing lesions, suggesting a potential role of this method as a quantitative imaging biomarker to detect subtle blood-brain barrier damage.

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