Magnetic Resonance Fingerprinting enables measuring T1-shortening in multiple sclerosis lesions after contrast media administration
Graziella Donatelli1,2, Paolo Cecchi1,2, Gianmichele Migaleddu1, Matteo Cencini3, Claudio D'Amelio4, Guido Buonincontri3, Luca Peretti2,3,4, Livia Pasquali4, Michela Tosetti2,3, Mirco Cosottini4, and Mauro Costagli3,5
1Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, 2IMAGO 7 Research Foundation, Pisa, Italy, 3IRCCS Stella Maris, Pisa, Italy, 4University of Pisa, Pisa, Italy, 5Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Sciences, University of Genoa, Genoa, Italy
Quantitative maps of T1-shortening (ΔT1) related to intra-venous contrast media administration are obtained in patients with Multiple Sclerosis by using 3D Quantitative Transient-state Imaging. Statistically significant ΔT1 is observed not only in enhancing lesions, but also in some non-enhancing lesions, suggesting a potential role of this method as a quantitative imaging biomarker to detect subtle blood-brain barrier damage.
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