Comparing myelin-sensitive markers MWF, ihMTR, and MTsat in healthy and normal-appearing brain tissue and multiple sclerosis lesions
Ronja C. Berg1, Viola Pongratz2, Markus Lauerer2, Thomas Amthor3, Guillaume Gilbert4, Aurore Menegaux1, Claus Zimmer1, Christian Sorg1, Mariya Doneva3, Irene Vavasour5, Mark Mühlau2, and Christine Preibisch1
1Department of Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany, 3Philips Research Europe, Hamburg, Germany, 4MR Clinical Science, Philips Healthcare, Mississauga, ON, Canada, 5Department of Radiology, University of British Columbia, Vancouver, BC, Canada
Measurement of myelin concentration could provide valuable information on the integrity of brain tissue. Several myelin-sensitive magnetic resonance imaging methods have been developed. Here, we compared myelin water fraction (MWF), inhomogeneous magnetization transfer ratio (ihMTR) and magnetization transfer saturation (MTsat) in healthy volunteers and patients with multiple sclerosis (MS). We found highest correlation between MWF and ihMTR but all three measures showed clearly reduced values in MS lesions compared to healthy or normal-appearing white matter. However, the measures varied in differentiating between various WM regions and between peri-lesional tissue and more distant normal-appearing WM.
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