Measurement of myelin concentration could provide valuable information on the integrity of brain tissue. Several myelin-sensitive magnetic resonance imaging methods have been developed. Here, we compared myelin water fraction (MWF), inhomogeneous magnetization transfer ratio (ihMTR) and magnetization transfer saturation (MTsat) in healthy volunteers and patients with multiple sclerosis (MS). We found highest correlation between MWF and ihMTR but all three measures showed clearly reduced values in MS lesions compared to healthy or normal-appearing white matter. However, the measures varied in differentiating between various WM regions and between peri-lesional tissue and more distant normal-appearing WM.
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