This study evaluated myelin water fraction (MWF) estimates in chronic MS lesions against contralateral normal appearing white matter (NAWM) of pediatric onset MS patients (POMS). Accelerated 2D multi-slice CPMG acquisitions provided near full brain coverage. Two methods were used to estimate the myelin fractions, as well as intra-/extra- axonal (IE) associated water and CSF water. Significant differences were found between the group measures. Further comparison of NAWM in POMS showed significant differences with whole-white matter in a control group. Our results support that a multi-component T2 analysis can provide quantitative insights into lesional and non-lesional disease burden in POMS.