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Abstract #0891

Multi-Component T2 Characterization of Lesions in Pediatric Onset Multiple Sclerosis

Serge Didenko Vasylechko1,2, Fedel Machado-Rivas1,2, Camilo Jaimes1,2, Mark P. Gorman2,3, Leslie Benson2,3, Simon K. Warfield1,2, Sila Kurugol1,2, and Onur Afacan1,2
1Radiology, Boston Children's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Neurology, Boston Children's Hospital, Boston, MA, United States


This study evaluated myelin water fraction (MWF) estimates in chronic MS lesions against contralateral normal appearing white matter (NAWM) of pediatric onset MS patients (POMS). Accelerated 2D multi-slice CPMG acquisitions provided near full brain coverage. Two methods were used to estimate the myelin fractions, as well as intra-/extra- axonal (IE) associated water and CSF water. Significant differences were found between the group measures. Further comparison of NAWM in POMS showed significant differences with whole-white matter in a control group. Our results support that a multi-component T2 analysis can provide quantitative insights into lesional and non-lesional disease burden in POMS.

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