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Abstract #0892

Differences in myelin measures between slowly evolving and non-slowly evolving lesions

Irene Margaret Vavasour1, Colm Elliott2, Doug Arnold2,3, Laura Gaetano4, David Clayton5, Stefano Magon4, Ulrike Bonati4, Wei Wei4, Anthony Traboulsee1, and Shannon Kolind1
1University of British Columbia, Vancouver, BC, Canada, 2NeuroRX Research, Montreal, QC, Canada, 3McGill University, Montreal, QC, Canada, 4F Hoffmann-La Roche Ltd, Basel, Switzerland, 5Genentech Inc, San Francisco, CA, United States


Multiple sclerosis (MS) slowly evolving lesions (SELs) are defined on MRI as contiguous regions of pre-existing lesions with constant and concentric local expansion on conventional T1-weighted and T2-weighted images. Myelin-related changes using myelin water fraction (MWF) and magnetization transfer ratio (MTR) in SELs and non-SELs were measured over 192 weeks in patients with relapsing MS. SELs showed reduced myelin measures at baseline compared to non-SELs. Furthermore, over the 4 years, only SELs, and not non-SELs, showed a significant mean decrease in MWF and increase in T1. Both results are indicative of progressive demyelination in this subgroup of chronic lesions.

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