Abstract #0893
Spinal Cord Lesions and Brain Grey Matter Atrophy Predict 5-Year Disease Worsening in Multiple Sclerosis: A Multicentre Study
Paola Valsasina1, Maria A. Rocca1,2,3, Alessandro Meani1, Loredana Storelli1, Claudio Gobbi4,5, Chiara Zecca4,5, Frederik Barkhof6,7, Menno M Schoonheim8, Eva Strijbis7, Hugo Vrenken6,7, Antonio Gallo9, Alvino Bisecco9, Olga Ciccarelli10, Marios Yiannakas10, Alex Rovira11, Jaume Sastre-Garriga12, Jacqueline Palace13, Lucy Matthews13, Achim Gass14, Philipp Eisele14, Carsten Lukas15, Barbara Bellenberg15, Monica Margoni1, Paolo Preziosa1,2, and Massimo Filippi1,2,3,16,17
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy, 4Neurology Clinic, MS Center/ Headache Center, Neurocenter of Southern Switzerland, Lugano, Switzerland, 5Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland, 6Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam UMC, location Vumc, Amsterdam, Netherlands, 7Department of Neurology, MS Center Amsterdam, Amsterdam UMC, location Vumc, Amsterdam, Netherlands, 8Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam UMC, location Vumc, Amsterdam, Netherlands, 9Department of Advanced Medical and Surgical Sciences, and 3T MRI-Center, University of Campania “Luigi Vanvitelli”, Naples, Italy, 10NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, 11Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 12Department of Neurology/Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 13Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 14Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany, 15Institute of Neuroradiology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany, 16Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 17Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy
Synopsis
Aim of this study was to evaluate the independent role of brain and cervical cord damage in predicting 5-year clinical disability worsening in a multicentre cohort of multiple sclerosis patients. Results showed that cortical atrophy and spinal cord damage, together with baseline disability and progressive disease phenotype, independently predicted 5-year disability worsening (C-index=0.81). Older age, higher clinical disability and cord lesion number independently predicted conversion to a progressive disease phenotype (C-index=0.91). Focal spinal cord lesions and cortical atrophy had also a role in predicting clinically-relevant disability milestones at 5 years.
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