Blood-brain barrier permeability to water has been measured as the exchange time (Texch) between intra- and extra-vascular spaces using multi-TE arterial spin labelling (ASL). This relies on small signal changes associated with labelled blood water delivery, making it challenging to achieve high accuracy in short yet clinically-desirable scan durations. In this study, we used an optimal sampling framework to generate pseudo-continuous ASL protocols that were jointly optimised for delays and echo times. Simulation showed that while optimised protocols had overall improvements in parameter estimation compared to conventionally even-sampled protocols, accurately estimating Texch could not be achieved without sacrificing CBF accuracy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords