Combined optimisation of delays and echo times for blood-brain barrier permeability measurements using multi-TE pCASL MRI
Logan X Zhang1 and Michael A Chappell2,3,4
1Department of Engineering Science, Institute of Biomedical Engineering, Nottingham, United Kingdom, 2Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging, FMRIB, Oxford, United Kingdom, 3School of Medicine, University of Nottingham, Radiological Sciences, Division of Clinical Neurosciences, Nottingham, United Kingdom, 4School of Medicine, University of Nottingham, Sir Peter Mansfield Imaging Centre and Mental Health & Clinical Neurosciences, Nottingham, United Kingdom
Blood-brain barrier permeability to water has been measured as the exchange time (Texch) between intra- and extra-vascular spaces using multi-TE arterial spin labelling (ASL). This relies on small signal changes associated with labelled blood water delivery, making it challenging to achieve high accuracy in short yet clinically-desirable scan durations. In this study, we used an optimal sampling framework to generate pseudo-continuous ASL protocols that were jointly optimised for delays and echo times. Simulation showed that while optimised protocols had overall improvements in parameter estimation compared to conventionally even-sampled protocols, accurately estimating Texch could not be achieved without sacrificing CBF accuracy.
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