Abstract #0922

Evaluation of microsatellite instability in endometrial carcinoma by amide proton transfer imaging and diffusion kurtosis imaging

Shifeng Tian¹, Ailian Liu^1,2, Xing Meng¹, Lihua Chen¹, Nan Wang¹, Liangjie Lin³, Geli Hu³, and Jiazheng Wang³

¹the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Dalian Medical Imaging artificial intelligence engineering technology research center, Dalian, China, ³Philips Healthcare, Beijing, China

Synopsis

Microsatellite instability (MSI) is one of the four types of endometrial carcinoma (EC) molecular classification based on The Cancer Genome Atlas (TCGA) [1], which refers to the high mutation load caused by the failure of EC to correct certain errors in small sequence replication due to the abnormal function of DNA mismatch repair system [2]. The purpose of this study is to explore the value of multiple quantitative parameters of APT and DKI sequences in evaluating EC MSI status.

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