Evaluation of microsatellite instability in endometrial carcinoma by amide proton transfer imaging and diffusion kurtosis imaging
Shifeng Tian1, Ailian Liu1,2, Xing Meng1, Lihua Chen1, Nan Wang1, Liangjie Lin3, Geli Hu3, and Jiazheng Wang3
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Dalian Medical Imaging artificial intelligence engineering technology research center, Dalian, China, 3Philips Healthcare, Beijing, China
Microsatellite instability (MSI) is one of the four types of endometrial carcinoma (EC) molecular classification based on The Cancer Genome Atlas (TCGA) , which refers to the high mutation load caused by the failure of EC to correct certain errors in small sequence replication due to the abnormal function of DNA mismatch repair system . The purpose of this study is to explore the value of multiple quantitative parameters of APT and DKI sequences in evaluating EC MSI status.
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