Abstract #0926

VERDICT-MRI Analysis of False Positives in Prostate Mp-MRI

Snigdha Sen¹, Vanya Valindria¹, Hayley Pye², Alistair Grey³, Aiman Haider⁴, Alex Freeman⁴, Caroline Moore³, Hayley Whitaker², Shonit Punwani⁵, Saurabh Singh⁵, and Eleftheria Panagiotaki¹

¹Centre for Medical Image Computing, University College London, London, United Kingdom, ²Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom, ³Department of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁴Department of Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁵Centre for Medical Imaging, University College London, London, United Kingdom

Synopsis

Mp-MRI has moderate specificity for the diagnosis of prostate cancer, resulting in many false positive results and unnecessary biopsies for patients with other prostatic diseases. This work presents an approach using VERDICT-MRI to investigate differences in microstructural parameter estimates between normal prostate tissue, false positive lesions and clinically-significant cancer. The VERDICT intracellular volume fraction and intrinsic diffusivity in the extracellular-extravascular space can discriminate false positive lesions with greater accuracy than the clinical ADC from mp-MRI. These results show VERDICT has the potential to identify false positives and reduce unnecessary biopsies in prostate patients.

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