Single-shot EPI (sshEPI) DWI still suffers from distortion and blurring. Multi-shot EPI (mshEPI) DWI called IRIS enables to reduce image distortion and blurring. A total of 142 patients with suspected prostate cancer (PC) underwent mpMRI including sshEPI DWI and IRIS under the same scan time. The image quality and diagnostic performance of the lesions were compared between sshEPI DWI and IRIS. IRIS improved image distortion and blurring compared to sshEPI DWI, and also suggested a similar or higher diagnostic performance compared to sshEPI DWI.