Gleason score (GS) is currently clinical predictor of prostate cancer (PCa) mortality. The present study investigates the metabolic profile of blood plasma for distinguishing aggressive PCa patients from non aggressive using targeted 1H-NMR metabolomics. A significantly higher concentration of lactate, pyruvate, choline, dimethylamine, glucose, betaine and lower concentration of leucine, isoleucine, valine, histidine, phenylalanine, and tyrosine were observed in patients with GS 8-10 as compared to patients with GS 7 and 6. Our results suggested that pathway alterations, amino acids, phospholipids and glucose related to PCa progression. Identifying biomarker/s associated with GS can be improved diagnosis and treatment.
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