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Abstract #0930

Semi-Quantitative Analysis of Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography in the Legs of Primary Lymphoedema Patients

Michael Mills1, Malou Van Zanten1, Julian Pearce2, Bernard Ho2, Kristiana Gordon1,2, Peter S Mortimer1,2, Pia Ostergaard1, and Franklyn A Howe1
1St George's University of London, London, United Kingdom, 2St George's University Hospitals NHS Foundation Trust, London, United Kingdom


Despite its prevalence, methods for investigating lymphoedema (chronic tissue swelling due to abnormal lymphatic functioning) remain limited. Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography (DCE-MRL) allows identification of lymph vessels in both healthy and lymphoedematous limbs, however quantitative analyses are lacking. DCE-MRL data was acquired for 30 minutes in lymphoedematous (n=7) and healthy limbs (n=4), with estimates of lymphatic vessel signal characteristics compared between groups. Maximum enhancement compared to baseline was significantly increased in healthy volunteers, while other metrics were similar. Larger groups and longer imaging sessions are likely required to detect additional differences.

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