The spatial distribution of lipid composition in breast has a major role in breast cancer prevention, with deregulation of lipid metabolism identified in BRCA1/2 genetic mutation carriers. Neoplastic tubule formation, a key component of grading score, is directly associated with cellularity, with significant implications on prognosis. Lipid composition measurement through biochemical extraction is invasive, while conventional spectroscopic imaging demands long acquisition time. Novel chemical shift-encoded imaging (CSEI) allows lipid composition mapping of the whole breast in a clinically acceptable timeframe. We set out to examine the relationship between peri-tumoural lipid composition and tubule formation using CSEI in breast tumours.
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