Abstract #0936

Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema

Rachelle Crescenzi^1,2,3, Paula Donahue⁴, Maria Garza⁵, Chelsea A Lee⁶, Niral J Patel⁶, Victoria Gonzalez⁷, Sky Jones⁵, and Manus J Donahue^5,8

¹Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷School of Medicine, The City College of New York, New York, NY, United States, ⁸Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

The overall goal of this work is to apply Dixon fat-water MRI to test fundamental hypotheses regarding the role of elevated adiposity in breast cancer treatment-related lymphedema (BCRL) condition severity. BCRL is a common co-morbidity of breast cancer therapies, yet factors that contribute to BCRL progression remain incompletely characterized. We observed that adiposity quantified by MRI is elevated in the affected upper extremity and torso of women with BCRL and increases with condition severity. As such, Dixon MRI may provide a surrogate marker of BCRL onset and may help to inform the varied course of lymphedema progression.

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