Abstract #0936
Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema
Rachelle Crescenzi1,2,3, Paula Donahue4, Maria Garza5, Chelsea A Lee6, Niral J Patel6, Victoria Gonzalez7, Sky Jones5, and Manus J Donahue5,8
1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 6Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States, 7School of Medicine, The City College of New York, New York, NY, United States, 8Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States
Synopsis
The overall goal of this work is to apply Dixon fat-water MRI to test fundamental hypotheses regarding the role of elevated adiposity in breast cancer treatment-related lymphedema (BCRL) condition severity. BCRL is a common co-morbidity of breast cancer therapies, yet factors that contribute to BCRL progression remain incompletely characterized. We observed that adiposity quantified by MRI is elevated in the affected upper extremity and torso of women with BCRL and increases with condition severity. As such, Dixon MRI may provide a surrogate marker of BCRL onset and may help to inform the varied course of lymphedema progression.
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