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Abstract #0940

Evaluation of Multiparametric Magnetic Resonance Imaging to assist Adaptive Radiotherapy in Prostate Cancer – an interim report

Angela Turnbull1, N. Jane Taylor2, Amish Lakhani2, William McGuire2, Rachael Bowie2, Roberto Alonzi3, and Alan Mcwilliam4
1Radiotherapy Physics, Mount Vernon Cancer Centre, Northwood, United Kingdom, 2Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, United Kingdom, 3Mount Vernon Cancer Centre, Northwood, United Kingdom, 4The Christie NHS Foundation Trust and Division of Cancer Services and University of Manchester, Manchester, United Kingdom


Initial results of a prostate cancer study investigating whether multiparametric MRI (MP-MRI), involving diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI, can predict or assess tumour response to radiotherapy (RT) and potentially support adaptive radiotherapy for high-risk patients. Adaptive radiotherapy is a treatment technique utilised to minimise radiation related toxicity. For some cancers it is possible to adapt radiotherapy according to physical changes that occur during treatment. This is not appropriate for prostate cancer treatment since observable changes are generally due to rectal movement, however it may be possible to use multiparametric MRI (MP-MRI) to measure treatment response.

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