Bone metastasis is an important issue in the management of prostate cancer, and can drastically alter the treatment strategy. PET/CT has been widely used in the diagnosis of bone metastasis; however, the high cost and radiation exposure limit its extensive clinical applications. APT-weighted imaging and IVIM, recent developed function-oriented MRI sequences, allow for a non-invasive visualization of tissue composition and microscopic information without the need for contrast agents. Results of this study indicate the APT value and IVIM parameters can effectively predict bone metastases in prostate cancer. A combination of APT and D* mono can further improve the prediction performance.