Short- and long-term changes of ADC and rF% in patients with bone metastases from breast cancer
Alberto Colombo1, Eleonora Giardini2, Paul Eugene Summers1, Paola Pricolo1, Fabio Zugni1, Maddalena Belmonte1, and Giuseppe Petralia3,4
1Division of Radiology, IEO European Institute of Oncology IRCCS, Milan, Italy, 2Degree course in Medical radiology, imaging and radiotherapy techniques, University of Milan, Milan, Italy, 3Precision Imaging and Research Unit, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, Milan, Italy, 4Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Evaluating short and long-term apparent diffusion coefficient (ADC) and relative fat fraction (rF%) changes could provide a better understanding of therapy response of bone metastases from breast cancer. Baseline ADC and rF% values computed from whole-body MRI, were compared with those measured at 12 and 36 week evaluations after treatment start. ADC and rF% significantly increased in responders at 12-weeks. At 36-weeks, ADC values range broadened, while rF% further increased. Short-term ADC and rF% changes are consistent with previous reports. Long-term changes highlight two patterns of response in which either high diffusion or fat repopulation prevail.
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