Abstract #0943

Short- and long-term changes of ADC and rF% in patients with bone metastases from breast cancer

Alberto Colombo¹, Eleonora Giardini², Paul Eugene Summers¹, Paola Pricolo¹, Fabio Zugni¹, Maddalena Belmonte¹, and Giuseppe Petralia^3,4

¹Division of Radiology, IEO European Institute of Oncology IRCCS, Milan, Italy, ²Degree course in Medical radiology, imaging and radiotherapy techniques, University of Milan, Milan, Italy, ³Precision Imaging and Research Unit, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, Milan, Italy, ⁴Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

Synopsis

Evaluating short and long-term apparent diffusion coefficient (ADC) and relative fat fraction (rF%) changes could provide a better understanding of therapy response of bone metastases from breast cancer. Baseline ADC and rF% values computed from whole-body MRI, were compared with those measured at 12 and 36 week evaluations after treatment start. ADC and rF% significantly increased in responders at 12-weeks. At 36-weeks, ADC values range broadened, while rF% further increased. Short-term ADC and rF% changes are consistent with previous reports. Long-term changes highlight two patterns of response in which either high diffusion or fat repopulation prevail.

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