Evaluating short and long-term apparent diffusion coefficient (ADC) and relative fat fraction (rF%) changes could provide a better understanding of therapy response of bone metastases from breast cancer. Baseline ADC and rF% values computed from whole-body MRI, were compared with those measured at 12 and 36 week evaluations after treatment start. ADC and rF% significantly increased in responders at 12-weeks. At 36-weeks, ADC values range broadened, while rF% further increased. Short-term ADC and rF% changes are consistent with previous reports. Long-term changes highlight two patterns of response in which either high diffusion or fat repopulation prevail.
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