Abstract #0970

The Effect of Label Crossing the Blood-CSF barrier on Partial Volume Correction: source of error or opportunity for quantification?

Leonie Petitclerc^1,2,3, Lydiane Hirschler^1,3, Iris Asllani^4,5, and Matthias J.P. van Osch^1,2,3

¹C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Clinical Imaging Science Center, University of Sussex, Sussex, United Kingdom, ⁵Biomedical Engineering, Rochester Institute of Technology, Rochester, NY, United States

Synopsis

Partial volume correction in ASL typically neglects CSF signal, however we have recently shown that some labeled signal crosses the blood-CSF barrier at a measurable level. Here we show the effect of including CSF in PVC, in simulated and in-vivo data. CSF-PVC reduced error on GM perfusion by ~10% in simulated data, with higher error when more CSF is present (including at longer LD and PLD). The difference between CSF-PVC and non-CSF-PVC GM signal in vivo was also ~10%. Comparing PVC signal in CSF to long-TE ASL signal suggests that BCSFB characterization may be possible without the acquisition of ultra-long-TE.

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