High Resolution Ex Vivo Diffusion Tensor Distribution MRI of Neural Tissue
Kulam Najmudeen Magdoom1,2,3, Michal E. Komlosh1,2,3, Saleem Kadharbatcha1,3, Dario Gasbarra4, and Peter J. Basser2,3
1The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc.,, Bethesda, MD, United States, 2Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Healt, Bethesda, MD, United States, 3Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, United States, 4University of Helsinki, Helsinki, Finland
Neural tissue microstructure plays a key role in developmental, physiological, and pathophysiological processes. Diffusion tensor distribution (DTD) MRI is a promising approach to resolve sub-voxel microstructural features using multiple diffusion encodings. In this study, we have applied a novel DTD framework and pulse sequence to investigate its capabilities in revealing neural tissue microstructure. We present high resolution data acquired using an excised visual cortex and cervical spinal cord of a macaque monkey. The results show DTD MRI untangles size, shape and orientation heterogeneity within a voxel and parcellates tissue consistent with histological findings.
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