Neural tissue microstructure plays a key role in developmental, physiological, and pathophysiological processes. Diffusion tensor distribution (DTD) MRI is a promising approach to resolve sub-voxel microstructural features using multiple diffusion encodings. In this study, we have applied a novel DTD framework and pulse sequence to investigate its capabilities in revealing neural tissue microstructure. We present high resolution data acquired using an excised visual cortex and cervical spinal cord of a macaque monkey. The results show DTD MRI untangles size, shape and orientation heterogeneity within a voxel and parcellates tissue consistent with histological findings.
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