Abstract #0977

High Resolution Ex Vivo Diffusion Tensor Distribution MRI of Neural Tissue

Kulam Najmudeen Magdoom^1,2,3, Michal E. Komlosh^1,2,3, Saleem Kadharbatcha^1,3, Dario Gasbarra⁴, and Peter J. Basser^2,3

¹The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc.,, Bethesda, MD, United States, ²Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Healt, Bethesda, MD, United States, ³Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, United States, ⁴University of Helsinki, Helsinki, Finland

Synopsis

Neural tissue microstructure plays a key role in developmental, physiological, and pathophysiological processes. Diffusion tensor distribution (DTD) MRI is a promising approach to resolve sub-voxel microstructural features using multiple diffusion encodings. In this study, we have applied a novel DTD framework and pulse sequence to investigate its capabilities in revealing neural tissue microstructure. We present high resolution data acquired using an excised visual cortex and cervical spinal cord of a macaque monkey. The results show DTD MRI untangles size, shape and orientation heterogeneity within a voxel and parcellates tissue consistent with histological findings.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.