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Abstract #0978

Time-dependent diffusion and kurtosis in the extra-axonal space from 3D electron microscopy substrates of injured rat brain white matter

Ricardo Coronado-Leija1, Hong-Hsi Lee2, Ali Abdollahzadeh3, Jussi Tohka3, Alejandra Sierra3, Els Fieremans1, and Dmitry S Novikov1
1Radiology, New York University School of Medicine, New York, NY, United States, 2Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3University of Eastern Finland, Kuopio, Finland


In this work, we perform Monte Carlo simulations of diffusion in the extra-axonal space segmented from realistic 3D electron microscopy substrates. Simulations in sham and TBI rat brains confirm the universality of the power-law functional form of the axial and radial time-dependent diffusion $$$D^{\parallel,\perp}(t)$$$ and kurtosis $$$K^{\parallel,\perp}(t)$$$. We characterize the changes caused by TBI, finding that the dependence of long-time asysmptote $$$D^{\perp}_\infty$$$ on the extra-axonal volume fraction follows Archie's law. We also validate the theoretically predicted relationship between the power-law tails of $$$D(t)$$$ and $$$K(t)$$$.

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