Optimised Temporal Diffusion Ratio for Imaging Restricted Diffusion
William Richard Warner1, Andrada Ianus2, Noam Shemesh2, Malwina Molendowska3, Derek Jones3, Flavio Dell'Acqua4, Marco Palombo3,5, and Ivana Drobnjak1
1Computer Science Department, University College London, London, United Kingdom, 2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 3Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 4NatBrainLab, King's College London, London, United Kingdom, 5School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
Temporal Diffusion Ratio (TDR) is a recently proposed dMRI technique, with potential for mapping areas of restricted diffusion. We optimise the TDR diffusion sequences in simulation to provide maximum contrast for a range of restricted structures, finding sequence shapes and the optimal HARDI subset size for calculating TDR. We then demonstrate the results experimentally in-vivo on the human brain, and ex-vivo using a pre-clinical scanner on the mouse brain.
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