Temporal Diffusion Ratio (TDR) is a recently proposed dMRI technique, with potential for mapping areas of restricted diffusion. We optimise the TDR diffusion sequences in simulation to provide maximum contrast for a range of restricted structures, finding sequence shapes and the optimal HARDI subset size for calculating TDR. We then demonstrate the results experimentally in-vivo on the human brain, and ex-vivo using a pre-clinical scanner on the mouse brain.
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